Albuminomics
Albuminomics is the study of the post-translational modifications (PTMs) of human serum albumin — the many chemically modified forms, or proteoforms, that a single albumin molecule can take — and their use as functional and structural biomarkers of liver disease, oxidative stress, and metabolic health.
Because albumin is synthesised exclusively by the liver and circulates for about three weeks, it acts as a long-lived molecular recorder: its modifications reflect weeks of metabolic and oxidative stress. Reading that record is what albuminomics does.
This site is an open, interlinked knowledge base curated by the group that develops these methods at INSERM UMR1248 / CHU Limoges. It is released under CC BY 4.0 — reuse freely with attribution.
Start here
- What is albuminomics? — the concept, in one page
- History of the inventions — from exchangeable copper to the SEB test and isoform profiling
- Human serum albumin (HSA) — the central molecule
- Glossary — key terms defined
Explore by theme
- Concepts — Cysteinylation · Glycation · Oxidation · Carbonylation · Oxidative stress
- Methods — SEB test · Top-down proteomics · LC-MS · SRM
- Diseases — DILI · Liver fibrosis · Acute liver failure · Diabetes
- Biomarkers — HSA isoforms in liver disease · CDT · HbA1c by top-down
- Patents — Portfolio overview · 104458 · Isoform etiology profiling · Absolute quantification
- Key studies — ALBOM: multi-class fibrosis staging · SEB test · Absolute quantification method
Who maintains this
Curated by Dr Souleiman El Balkhi and colleagues, Pharmacology–Toxicology & Pharmacovigilance, INSERM UMR1248, CHU Limoges, France. See the invention history for the scientific lineage.
This site provides scientific and educational information. It is not medical advice.